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The Toxic Effects and Health Risks of Tattoos

Typical redness and swelling on same day of getting tattoo.

Typical redness and swelling on same day of getting tattoo.

Tattooing: A Brief History

Much has been written about the hazards of tattooing if practiced under unsanitary conditions. That said, even less attention has been directed to the potential latent health effects of tattoo inks. The lack of attention to these effects is shocking since tattoos are one of the most popular and prevalent forms of body art. The practice of tattooing is centuries old and is central to some cultures.

Tattooing has been practiced throughout most of the world, though it is rare in China and among people with darkly pigmented skin. Evidence of the practice has even been found in over 4,000-year-old Egyptian mummies and in 5,000-year "Iceman" corpses preserved in ice. It is thought the word “tattoo” entered English and European languages in 1769, having been recorded by James Cook’s Tahiti expedition. In 1891, the first electric tattoo device was patented in the US.

Interest in tattoos has waxed and waned in US and European cultures. Those who object to tattoos would point to their use on prisoners and Nazi concentration camp internees. Religious objection to tattoos can be found in Leviticus 19:28: “You shall not make any cuttings in your flesh on account of the dead or tattoo any marks upon you.”

The practice of tattooing seems to have now become mainstream. Young adults and teens worldwide are having dangerous compounds and chemicals injected under their skin for the sake of body art. The trend started surging in the early 1990s. By 2003 it was projected that 36% of 25- to 29-year-olds in the US had at least one tattoo. That makes tattoos a pretty big business—and an even bigger health concern.

Tattoos and FDA Regulation

Did you know that there is no federal oversight of tattooing? Although tattoo businesses in the US fall under the purview of the Federal Drug Administration (FDA), the agency has not offered any guidelines or regulations for how tattoo parlors should operate. Their position has been: “Because of other public health priorities and a previous lack of evidence of safety concerns, FDA has not traditionally regulated tattoo inks or the pigments used in them.” Therefore, if an establishment claims that its tattoo business or tattoo inks are approved or certified by the FDA, it is simply not true.

The FDA does, however, acknowledge reports of adverse short- and long-term reactions to tattoo ink, including inflammation, itching after exposure to the summer sun, and reports of adverse reactions to tattooed make-up.

Risks Acknowledged by FDA

  • Infections such as HIV and hepatitis related to reused needles.
  • Allergic reactions to temporary and permanent tattoo inks.
  • Scarring as a result of getting a tattoo, or tattoo removal.
  • Granulomas in the form of large or small bumps that form to encapsulate foreign substances, such as tattoo ink particles.
  • Burning and swelling of tattoos in MRI machines due to metal components in tattoo inks.

FDA Research on Tattoos

The FDA and medical providers have determined many tattoo inks contain “industrial strength” pigments suitable for automotive paint and printers’ ink. The following issues will be explored by the FDA’s National Center for Toxicological Research (NCTR):

  • The chemical make-up of tattoo inks and how the inks are broken down by the body
  • Short- and long-term impact of tattoo ink pigments
  • Body response to inks with sunlight and laser

State Regulation of Tattoo Parlors

Is anyone watching the shop?

The states are. That's where most regulation of tattoo parlors happens. That means, however, that the level of rules and oversight varies. California’s Proposition 65 requires tattoo businesses to warn customers that tattoo pigments contain heavy metals associated with birth defects, other reproductive injuries, and cancer. On the flip side, some states have very lax rules.

Other Tattoo Concerns

  • The US Red Cross imposes a 12-month wait for potential donors who have had a tattoo in a facility that is not state-regulated, or in a state that has no oversight of tattoo businesses.
  • In the UK there is no regulation for tattooing, and a 6-month wait to give blood is imposed after tattoos, with no exceptions.
  • Canada introduced legal tattoo services in the prisons to give prisoners a skill, and to reduce health risks such as hepatitis.
  • Plastic polymers are used in glow-in-the-dark inks. Polymerization occurs when particles mesh into a solid sheet of plastic under the skin.
  • Metal salts in tattoo pigment can cause burning and pain during MRI procedures. Some facilities are refusing to perform MRIs on clients with tattoos.
  • Some pigments, especially yellows, react to light and may break down into toxic components due to laser removal treatments. These toxins may, in turn, place a burden on the liver and kidneys.
  • The American Academy of Dermatology has voiced concern and identified an extensive list of potentially harmful ingredients and compounds in tattoo inks.

What's in Tattoo Inks?

Central to the issue, is that no one is sure what is in the inks. Manufacturers are not bound to divulge the ingredients of their pigments, and mixtures may be considered trade secrets. Professional tattoo ink pigments may be made from plants, plastics, iron oxides, or metal salts. Homemade inks may be made from dirt, soot, plants, pen ink, blood, or an unknown array of other possible ingredients.

Some Known Tattoo Inks Ingredients

Heavy Metals

  • Aluminum
  • Barium
  • Cadmium
  • Chromium
  • Cobalt
  • Copper
  • Iron
  • Lead
  • Mercury
  • Nickel
  • Titanium
  • Zinc

Metal Oxides

  • Ferrocyanide
  • Ferricyanide

Organic Chemicals

  • Azo chemicals
  • Naptha derivative chemicals
  • Carbon
  • Polycyclic compounds

Other Compounds

  • Antimony
  • Arsenic
  • Beryllium
  • Calcium
  • Lithium
  • Phosphorus
  • Selenium
  • Silica
  • Sulfur
  • Titanium dioxide
  • Polymethylmethacrylate (PMMA)
Adverse reactions are most common with red inks. Reactions are also prevalent with yellow inks.

Adverse reactions are most common with red inks. Reactions are also prevalent with yellow inks.

Common Ingredients of Inks by Color

Red: mercury, cadmium, iron, ferrocyanide, ferricyanide, naphtha-derived chemicals

Orange: cadmium, azo chemicals

Yellow: lead, cadmium, zinc, ferrocyanide, ferricyanide, azo chemicals

Green: lead, chromium, aluminum, copper, ferrocyanide, ferricyanide, azo chemicals

Blue: cobalt, copper, ferrocyanide, ferricyanide

Violet: aluminum, azo chemicals

Brown: iron, azo chemicals

Black: nickel, iron, carbon as soot or ash, black henna

White: lead, zinc, titanium, barium

Common Reactions to Tattoo Ink

Although data is not collected on allergic reactions, some sources suggest that most of the reactions are to the latex rather than the tattoo inks and recommend that clients ask tattoo artists to use non-latex gloves.

Reports indicate allergic reactions to tattoo inks are most common with red and yellow inks as well as white ink.

Red ink is also associated with complications after laser removal treatments and is known to contain mercy and azo chemicals.

The European Commission report from 2003 recounts:

  • A case of allergic skin reaction to cobalt blue, and many cases of reactions of red tattoo ink, of both azo compounds and inks of heavy metal composition.
  • Nodular granulomatous reactions, mostly related to azo or heavy metal red inks. One case developed in the red pigmented areas of a 37-year-old tattoo.
  • Sarcoidosis cases traced to red ink, black ink, and multiple colors of ink.

Pigment Carriers

Pigments are dissolved in a solvent to help “carry” the color from the needle to the skin. Carriers make ink application easier and help keep the ink mixed with the pigment and evenly distributed. Typical carriers are some form of alcohol or aldehyde. Alcohol-based carriers increase the permeability of the skin, increasing absorption into the bloodstream. Alcohol carriers are also known to amplify the carcinogenic effects of these tattoo inks.

Common Carriers

  • Water
  • Ethyl alcohol
  • Denatured alcohol
  • Methanol
  • Rubbing alcohol
  • Propylene glycol
  • Glycerine
  • Formaldehyde
  • Other aldehydes
One of my sister's tattoos, now 20 years old.

One of my sister's tattoos, now 20 years old.

European Commission Findings

The European Commission published Risks and Health Effects from Tattoos, Body Piercing and Related Practices in May of 2003. The team had identified health risks from tattooing and piercing, as well as lax or non-existent regulation of these industries. While the specific composition of tattoo ink was generally unknown, it was known, however, that organic industrial pigments and heavy metals were used, which had impurities and microbiological components.

One of the problems is that there have been few defined, targeted studies to examine risks for short- or long-term effects of tattoo inks. In examining many studies, including anecdotal reports of adverse effects, they developed a list of health risks that were “potentially associated with tattooing and piercing." Examination of the full report, however, reveals some findings that are worth paying attention to.

European Commission Findings of Possible Health Effects:

The commission findings can be categorized into five areas: infections, allergic reactions, cancer, behavioral changes, and skin diseases. Many of the effects are delayed, sometimes up to 20 years or longer. In my view, this is similar to the problems associated with silicone breast implants, agent orange exposure, and Gulf War Syndrome.


Infections are associated with poor hygienic conditions and risky practices such as the reuse of tattoo needles. Infections are understandably also associated with prison tattooing and have also been found in unlicensed tattoo facilities and artists. Known infections include:

Viral Infections:

  • hepatitis
  • skin infections

Bacterial Infections:

  • Toxic shock syndrome
  • Impetigo
  • Chancroid
  • Tetanus
  • Leprosy
  • Tuberculosis

Fungal Infections:

  • Zygomycosis
  • Sporotrichosis

Allergic Reactions

Allergic reactions associated with tattoos are almost exclusively associated with inks and pigment carriers. According to numerous case reports, allergic reactions are "not infrequent." These reactions include:

  • Skin irritation and urticaria
  • Lichenoid and granulomatous reactions
  • Lymphadenopathy
  • Pseudo lymphomas
  • Sarcoidosis


Skin cancers have formed within a tattoo and gone unnoticed until they began to extend beyond the boundaries into un-inked areas. These cancers include:

  • Malignant melanoma
  • Squamous cell carcinoma
  • Basal cell carcinoma

European Commission Recommendations

  • Systematic study of adverse health impacts
  • Regulation of facilities, materials/inks, workers
  • List of prohibited and permitted ingredients
  • Education and certification of tattoo artists

Other Findings

Nearly 40% of organic pigments used in tattoos are not approved even for cosmetic topical use. Almost 20% of pigments were cancer-causing aromatic amines.

Tattoo inks travel in the body. Black tattoo pigments have been found in lymph nodes. Further, these pigments look like metastases in the nodes, complicating the evaluation of cancer status.

Laser removal of tattoos has been shown to generate new chemical compounds that travel through the blood and lymph vessels. Cancer-causing compounds have also been generated.

Final Thoughts

There is no such thing as a safe tattoo. There are a reasonable number of studies and case reports pointing to the adverse health effects of tattoos. The lack of extensive definitive studies proving adverse effects is just that, a lack of studies. It is not proof that tattoo inks are safe.


I searched and printed a small mountain of articles to read and assimilate to write this article! Here are my primary resources:

This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional. Drugs, supplements, and natural remedies may have dangerous side effects. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.

Thanks for reading. Please leave a comment.

CaroleF on July 04, 2012:

Hi RM, Thanks for the article. I got a tattoo nearly 20 years ago when I was in my early 20's. Even though it is in a place not noticeable, I have regretted ever doing it. I have a need for removing it now but I've been diagnosed with an autoimmune disorder. Do you know of any products for removal that can be safer for the immune system? Such as gels, creams?

rmcrayne (author) from San Antonio Texas on January 16, 2012:

Love your comment miriam. It's really shocking, isn't it? And unfortunately it's deemed even more dangerous to have tattoos removed.

miriam on January 14, 2012:

I cant believe it!my friend is a tatooist & hes done a couple on me, knew there wasn't any real regulations except health & hygiene.i have 9 tatoos in total,they are all tastefull,mean something & I can cover them up.i have always used reputable,hygienic tatooists but now ive read this,it is frightening to think what I have put into my body.thank you for yout research it is such an eye opener!

rmcrayne (author) from San Antonio Texas on September 16, 2011:

Thanks for your great comment Gary. It’s okay to inject stuff under your skin that’s illegal in topical cosmetics. And the FDA is too busy with other things. Go figure.

Gary Shorthouse from Reading, UK on September 15, 2011:

Sometimes tattoos can look good, sometimes they can look disgusting, but after reading your article I now see that they are also very dangerous. I had no idea that such toxic chemicals are used in the tattooing inks. Many of those that you listed are banned from paints and glazes, so it is remarkable that some people are happy to be injected with them.

A chilling hub - I will never look at a tattoo in quite the same way again.

rmcrayne (author) from San Antonio Texas on August 13, 2011:

Jane, I think there is an initial restriction after freshly getting a tattoo. A reasonable time must pass to establish that the person did not get an infection or something. As far as transfusions, I'd think it's a similar situation to the studies about epidurals and anesthesia: there is concern that a needle pierced through the tattooed area may carry impurities or toxic materials from the tattoo deeper into the body, or into the blood stream. Avoid getting a needle stick thru tattooed areas.

jane on August 03, 2011:

thanks for the info.i have a question.-can a tattoo bearer donate or recive blood(transfusion)

AutmBlanche on May 17, 2010:

Extremely great article. Very informative indeed. I've been tattooing for years and managed to learn some things from this article. I'm definitely going to link to this... Lucky to have stumbled on it, thank you for posting =)

Money Glitch from Texas on April 17, 2010:

Hi RM, I rediscovered this hub while doing maintenance to my hub titled Tattoos for Breast Cancer Survivors. Wanted to let you know I have added a complimentary link to here to provide additional information about making a decision on doing a tattoo. Hopefully in a few days it will generate more traffic to us both. :)

Thanks MG!

bengriston on November 29, 2009:

Wow this is a lot of research. I personally have one small one and do not worry too much about long term effects. But for those with many I would have to wonder if it really does hurt them in the long run.

Amanda W from Pittsburgh on November 25, 2009:

Really great research. I'm a fan of tattoos myself and thought I'd looked into the regulations and adverse effects pretty thoroughly, but you've proven me wrong - I had no idea they were so unregulated.

rmcrayne (author) from San Antonio Texas on October 28, 2009:

Green Lotus and Money Glitch,

That would be great if this hub got great traffic! I think the traffic will be from parents, spouses, boy/girlfriends who do not want their loved one to get a tattoo!

The info is a hard sell though. People have become so complacent about what they put in, or on their bodies. I think eventually it will come out more and more that tattoos are linked with auto-immune disorders.

Thanks for recognizing the days of hard work that went into this hub!

Money Glitch from Texas on October 28, 2009:

Awesome hub with a lot of well researched information in one location. I would think that this is one of a kind and hopefully will generate a lot of traffic from people wanting a tattoo, but want to know the risks involved before getting one. Great Job!

Hillary from Atlanta, GA on October 28, 2009:

Incredible hub. I never knew how great the risks were. Thanks for creating this important hub. I hope it travels far beyond our HP community. So many of my friends think nothing of getting 'one more tattoo'. It think it can be as addicting as Hubpages!

rmcrayne (author) from San Antonio Texas on October 27, 2009:

Kimberly, thanks so much for recognizing how much work this piece was! I feel like I need to do at least one more article because of all the info that I have printed and in my head.

lyricsingray on October 27, 2009:

RM, you have done some huge research here-what a job, and one that's not talked about enough, I'm glad I got to read it, really well done, cheers, Kimberly

rmcrayne (author) from San Antonio Texas on October 27, 2009:

Thanks for reading and commenting vrajavala. I have wondered if many scriptural prohibitions are not just plain old health and safety advice and not religious at all. Sound advice at the time, and in many cases still sound.

The black henna has been used for permanent tattoos, which has been linked with health problems. Turkish women dip their fingertips in henna for celebrations like weddings.

vrajavala from Port St. Lucie on October 27, 2009:

Interesting biblical prohibition. I had no idea. In India, there is a prohibition as well, according to the Scriptures. Ladies do use Henna which is semi-permanent.

rmcrayne (author) from San Antonio Texas on October 27, 2009:

Thanks for reading and commenting judy and Lily! My vote, stay away from tattoos. They WILL increase the toxic load on your body.

Lily Rose from A Coast on October 27, 2009:

Very good, comprehensive information - I've really been wanting to get a tattoo, now I'm a bit nervous about it!

judydianne from Palm Harbor, FL on October 27, 2009:

I had no idea! Great research. Everyone should read this before getting a tattoo!